Aggregation of disease-related peptides.

TitleAggregation of disease-related peptides.
Publication TypeJournal Article
Year of Publication2020
AuthorsNguyen PH, Sterpone F, Derreumaux P
JournalProg Mol Biol Transl Sci
Volume170
Pagination435-460
Date Published2020
ISSN1878-0814
Abstract

Protein misfolding and aggregation of amyloid proteins is the fundamental cause of more than 20 diseases. Molecular mechanisms of the self-assembly and the formation of the toxic aggregates are still elusive. Computer simulations have been intensively used to study the aggregation of amyloid peptides of various amino acid lengths related to neurodegenerative diseases. We review atomistic and coarse-grained simulations of short amyloid peptides aimed at determining their transient oligomeric structures and the early and late aggregation steps.

DOI10.1016/bs.pmbts.2019.12.002
Alternate JournalProg Mol Biol Transl Sci
Citation Key2020|2117
PubMed ID32145950