Normal mode analysis as a prerequisite for drug design: Application to matrix metalloproteinases inhibitors

TitleNormal mode analysis as a prerequisite for drug design: Application to matrix metalloproteinases inhibitors
Publication TypeJournal Article
Year of Publication2006
AuthorsFloquet N, Maréchal J-D, Badet-Denisot M-A, Robert CH, Dauchez M, Perahia D
JournalFebs Lett.
Volume580
Pagination5130–5136
Date Publishedoct
Abstract

We demonstrate the utility of normal mode analysis in correctly predicting the binding modes of inhibitors in the active sites of matrix metalloproteinases (MMPs). We show the accuracy in predicting the positions of MMP-3 inhibitors is strongly dependent on which structure is used as the target, especially when it has been energy minimized. This dependency can be overcome by using intermediate structures generated along one of the normal modes previously calculated for a given target. These results may be of prime importance for further in silico drug discovery.

DOI10.1016/j.febslet.2006.08.037
Citation Key2006|1810