Modeling large-scale hinge-bent motions in docking.
 

Dina Schneidman & Ruth Nussinov, Tel Aviv University.
 
 

Proteins are very flexible molecules. The flexibility may range from small-scale side-chain motions to large-scale intra and inter domain motions or even partial refolding. In my talk I will focus on approaches to handle hinge-bent protein flexibility in docking algorithms. Hinge detection strategies will also be mentioned. I will discuss the problems of the current methods and the challenges of the field.  In addition, I will present various examples, including CAPRI targets.