I am always seeking for talented young researchers who would be interested in discussing research opportunities in my group. In addition to the specific calls mentioned below, any motivated candidate is encouraged to contact me to discuss about other opportunities, either from the ERC ABIOS grant, or from other sources of local or European funding that can be considered once a candidate has been identified.
In all cases, interested candidates should contact me by e-mail, together with an up-to-date curriculum vitae and contact information for one or two references.
Postdoc position from end of 2021
A postdoc position funded by the ERC ABIOS is now open to applicants.
Subject In modern cells, molecules are confined in a volume in the femtoliter range, resulting in concen-trations that critically enhance reaction rates. How can an efficient chemistry leading to the emergence of life take place in an ocean, a puddle or even a water droplet, which are 109-1036 times larger? Recent pioneer experiments have shown that thermally-driven processes such as thermophoresis can accumulate otherwise dilute precursors at localized spots acting as thermal traps for RNA strands oligomerization. Natural thermophoretic settings occur e.g. in the pores of hydrothermal vents on the ocean’s floor that may have played a key role in the appearance of biological chemistry. On a different perspective, the number of technological applications that use thermophoresis is burgeoning, including the manipulation of biomolecules in thermal traps, the measurement of protein-ligand affinity or applications in microfluidics.
Yet, a major limitation is that the nature of thermophoresis is still highly debated. The goal of this postdoc will be to use all-atom molecular dynamics simulations of in silico realizations of thermophoretic settings and analytical modeling to gain a deeper molecular understanding of this phenomenon. Building upon our recent advances on the topic (see e.g. https://doi.org/10.33774/chemrxiv-2021-bht06), we will focus on the comparison between aqueous solutions and model Lennard-Jones liquids, as well as on thermodiffusion in confined environments.
Research environment Our group has extensive experience in applying advanced simulation and theoretical tools to tackle a variety of questions, ranging from water ultrafast dynamics in aqueous solutions to the mechanical and thermal stability of proteins. We have access to state-of-the-art computing facilities that include a local mesoscale computer cluster. The postdoc salary includes generous health and social benefits, and a number of housing opportunities are available for foreign applicants. Funding is provided for 18 months (with a possible extension if necessary) by the European Research Council (Starting Grant ABIOS), following CNRS's salary policies bases on the candidate experience.
Requirements PhD in molecular physics or physical/theoretical chemistry. Strong simulation skills are required, as well as the use of at least one programming language.
Contact information Interested candidates should contact Guillaume Stirnemann as soon as possible (firstname.lastname@example.org), together with a curriculum vitae and contact information for one or two references.